Patient question
When a cardiomyopathy genetic testing report says 'variant of uncertain significance,' what questions should I ask during consultation?
Answer reviewed by Cheng Zhiqing, Department of Cardiology, the Second Affiliated Hospital of Zhejiang Chinese Medical University
Professional answer
Ask the ordering clinician or genetic counselor to explain what this result currently supports, what remains uncertain, and whether it affects the existing follow-up plan. You can also ask whether reinterpretation will be needed in the future and who will contact you with updates. Do not use this term alone to diagnose yourself or relatives, and do not change treatment based on it without medical guidance.